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Startups in the News

  • First Patient Dosed in X-Linked Retinitis Pigmentosa (XLRP) Treatment (RareDR)
    UF startup Applied Genetic Technologies Corporation announced that the first patient was dosed in its Phase 1/2 clinical trial evaluating the safety and efficacy of AGTC-501 for the treatment of X-linked retinitis pigmentosa (XLRP). The investigational adeno-associated virus (AAV-based) gene therapy, (rAAV2tYF-GRK1-RPGR), is a novel recombinant AAV vector expressing a human RPGR gene (rAAV2tYF-GRK1-RPGR) in patients with XLRP. XLRP is an inherited condition that affects young boys and men. It causes the development of night blindness and eventually leads to legal blindness by patients’ early forties.... Read more »
  • Altavian Awarded US Army TUAS Contract (Geospatial News)
    UF startup Altavian, Inc., a U.S. based Unmanned Aircraft System (UAS) engineering and manufacturing firm, announced the award of a $250MM Indefinite Delivery, Indefinite Quantity contract with the US Army. Under the Program Executive Office Aviation, Products Office for Tactical Unmanned Aircraft (TUAS), Altavian will be supporting the largest small UAS program in the world. The US Army Family of Systems, Unmanned Aircraft Systems (FoSUAS) includes the RQ-11, the RQ-20, supporting control and communications equipment, and other technologies to be fielded over the contract period of performance. All systems are designed to be carried by a single dismounted warfighter, quickly assembled, and deployed to provide immediate over-the-hill surveillance and reconnaissance. Altavian supports the mission of the Army to provide critical, real-time intelligence for warfighter protection and extended operational reach.... Read more »
  • AGTC Announces Completion of Enrollment of Phase 1/2 Clinical Study of Investigational Gene Therapy in Patients with X-Linked Retinoschisis (Globe Newswire)
    UF startup and UF Innovate | Sid Martin Biotech alumni company Applied Genetic Technologies Corporation announced the completion of enrollment in a clinical study of the company’s gene therapy product candidate, in collaboration with Biogen, for the treatment of x-linked retinoschisis (XLRS). AGTC is a biotechnology company conducting human clinical trials of adeno-associated virus (AAV)-based gene therapies for the treatment of rare diseases. This multicenter study is designed to evaluate the collaboration’s AAV vector expressing retinoschisin (rAAV2tYF-CB-hRS1) in patients with XLRS caused by mutations in the RS1 gene. Topline data are anticipated by Q4 2018 with the final analysis at the twelve-month time point. “There are currently no FDA approved treatment options for XLRS, a leading cause of macular degeneration in young men,” said Sue Washer, president and CEO of AGTC. “The completion of enrollment in this AAV trial represents another significant achievement in our gene therapy clinical development program- a milestone that may improve the lives of individuals affected by XLRS.”... Read more »
  • Cannabix Technologies Files FAIMS Cannabis Detection Patent (Globe Newswire)
    UF startup Cannabix Technologies Inc., developer of the Cannabix Marijuana Breathalyzer for law enforcement and the workplace, has filed a Patent Cooperation Treaty (“PCT”) application titled, “Device and Method for Detection of Cannabis and Other Controlled Substances Using FAIMS” (PCT/CA2017/000042). The agreement provides Cannabix exclusive worldwide rights in the area of breath analysis of controlled substances. Cannabix is developing an innovative FAIMS (field asymmetric waveform ion mobility spectrometry) based instrument for the detection of ∆9-tetrahydrocannabinol in human breath. In recent months the Company has been characterizing its Beta 3.0 Cannabix Marijuana Breathalyzer prototype performance measures both independently and coupled to a mass spectrometer (MS), in preparation for expanded field testing. This work has led to the design and development of several improvements to the device which are now being incorporated. The characterizing work has focused on better separation of several analytes in human breath that are similar in molecular mass and geometry to THC. Testing has included further temperature characterization and flow control. A unique gating system has been developed that allows switching between the standalone FAIMS detector and a conventional MS enabling rapid alternation between both mechanisms during a single breath, proving enhanced analysis capability.... Read more »
  • Exactech Knee Research Honored with Orthopaedic Research Society’s Best Implant Poster Award (Business Wire)
    UF startup Exactech, a leading developer and producer of bone and joint restoration products and biologic solutions for extremities, knee and hip, announced that its research, “Total Knee Arthroplasty Using a Contemporary Computer-Assisted Surgical System: A Review of Resection Alignment on 8,000 Clinical Cases,” received the Orthopedic Implant Section Best Poster Award at the 2018 Orthopaedic Research Society (ORS) Annual Meeting in New Orleans, La. The study was based on a large collection of technical reports on all the total knee arthroplasty cases performed in the entire application history of ExactechGPS®, Exactech’s surgeon-controlled computer-assisted surgery for improved reproducibility and efficiency in total joint arthroplasty. The results demonstrated high accuracy and precision in resection alignment with the use of the system by users with varying levels of experience.... Read more »

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