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NIH Multiple Principal Investigator Projects

The traditional NIH research project grant consists of a single Program Director/Principal Investigator (PD/PI) coordinating all efforts on an independent research project. Although this model clearly continues to work well and encourages creativity and productivity, it does not always work well for multidisciplinary efforts and collaboration. Increasingly, health-related research involves teams that vary in terms of size, hierarchy, location of participants, goals, disciplines, and structure. The multiple-PD/PI model supplements, and not replace, the traditional single PD/PI model, and allows applicants and their institution to identify more than one PD/PI on a single grant application. The goal is to encourage collaboration among equals when that is the most appropriate way to address a scientific problem. The availability of the Multiple PD/PI option encourages interdisciplinary and other team approaches to biomedical research. 

  1. Responsibility of Multiple PI’s: The decision to utilize the Multiple PI option is the responsibility of the investigators and should be determined based on the scientific goals of the project. Each multiple PI will have equal responsibility for leading and directing the project; each is equally accountable for the proper conduct of the program including fiscal oversight and submission of all required reports.
  2. At the time of Proposal Submissions: For all UF applications that propose a Multiple PI Project, the following criteria must be met prior to submission
    1. All proposed UF PIs must have PI status as defined in UF’s PI Eligibility Policy.
    2. All proposed non-UF PIs must have PI status as defined by their home institution. UF will treat non-UF PIs and their home institutions as subrecipients.
    3. All UF proposals must identify a UF PI as the Contact PI. The Contact PI will be responsible for relaying communications between all of the PIs, UF Officials and the Sponsor, where appropriate.
    4. The allocation of funds for each PI should be detailed in the grant application.
    5. The proposal is submitted thru one lead unit where dept and College sign-off on the proposal. All other UF PI’s must provided the federal assurance by signing-off on the proposal submission using UFIRST ad-hoc approval.
    6. All other normal proposal information is still required, for example subrecipient proposal and conflict of interest forms.
    7. Supplemental proposals must be routed with the Contact PI listed as the Principal Investigator in UFIRST.